International experts

Hazard, RIsk & Exposure Assessments

Because of our many years of experience in human and environmental safety assessments and our global outreach, knoell is perfectly positioned to provide a broad spectrum of services for registration packages in Europe an beyond.

With a team of about 40 toxicologist,  more than 70 environmental fate and modelling experts as well as approx. 45 ecotoxicologists  your assessments are in competent hands.

 

Standard and higher tier approaches

When it comes to the use of chemicals, human, environmental and ecological safety are key. Therefore, depending on the active ingredient, product and country of use, complex assessments form the core of most sets of documents required to obtain and maintain market access.

Standard assessments are calculations based on conservative assumptions and simple equations. Calculations can be e.g. performed using Microsoft Excel spreadsheets, sometimes provided as standardised 'tool' by the respective authorities,  or slightly more sophisticated models (e.g. the FOCUS suite for EU groundwater and surface water modelling) but still using conservative input parameters. In contrast, higher tier approaches gradually increase in complexity with each tier  of the models in order to depict the natural "real-life" conditions and possible effects as accurately as possible.

An example of how a higher tier approach could look like can be found here.

 

Computer based (in silico) modelS - QSAR, read-across, and more...

Years of experience in the various regulatory areas covering the different categories of chemical substances allowed knoell to establish a team specifically dedicated to developments and use of in silico model. For example the following tasks and questions can be supported by data derived from in silico  models

  • Early screening can deliver results to support your decision making processes at an early stage of R&D of new substances.
  • Obtained information can supplement experimental data in weight of evidence approaches.
  • Data can be used in order to meet the 3Rs principle: Replacement, Reduction and Refinement of animal testing.
  • Testing of all metabolites (and impurities) is practically impossible e.g. due to timeline constraints and/or technical limitations.

Learn more about the regulatory frameworks and questions where in silico models can be applied.

 

Endocrine Disruptor (ED) assessments

Our team of experts supports in all aspects of the highly complex and challenging Endocrine Disruptor (ED) assessment, tailored to your needs.

  • Assessment according to ECHA/EFSA ED Guidance
  • Literature & database search, QSAR profiling
  • Weight of evidence, mode of action analysis
  • Development & design of testing strategies
  • Screening of biocidal product co-formulants
  • Training courses

More information on Endocrine Disruptor assessments.

Further Reading

spalten3

Mitigation of surface runoff from agricultural fields by micro-dam technology

On sloped agricultural fields, water and sediment can be transported downhill as runoff and erosion. These processes cause loss of valuable soil...

Could Qsar modelling be used for some data gaps in REACH registration of polymers?

Polymers have been used in many industrial sectors including consumer goods, construction materials, the electrical industry, food contact materials

Regulating endocrine disruptors: Interfaces between legislations & related challenges

Endocrine Disruptors (EDs), their definition and criteria, together with feasible options for testing and assessment, have been extensively worked...

Explore the knoell library to learn more about our experts and expertise.

knoell publications